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Published on: October 4, 2022
Metastasis Suppressor Genes in Pancreatic Cancer: An Update
Arnav Bhattacharya1, Anirudh Santhoshkumar1, Hiroshi Kurahara2
1From the Department of Genetic Engineering, SRM Institute of Science and Technology, Kattankulathur, India.
Abstract:
Pancreatic cancer, especially pancreatic ductal adenocarcinoma (PDAC), has for long remained a deadly form of cancer characterized by high mortality rates resulting from metastasis to multiple organs. Several factors, including the late manifestation of the disease, partly amplified by lack of efficient screening methods, have hampered the drive to design an effective therapeutic strategy to treat this deadly cancer. Understanding the biology of PDAC progression and identifying critical genes regulating these processes are essential to overcome the barriers toward effective treatment. Metastasis suppressor genes have been shown to inhibit multiple steps in the metastatic cascade without affecting primary tumor formation and are considered to hold promise for treating metastatic cancers. In this review, we catalog the bona fide metastasis suppressor genes reported in PDAC and discuss their known mechanism of action.
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