Efficacy of Enrofloxacin in the Treatment of Canine Bacterial Pyoderma

Manon Paradis1, Suzie Lemay1, Danny W Scott2

  • 1Department of Medicine, Faculty of Veterinary Medicine, University of Montreal, St Hyacinthe, Quebec, Canada.

Veterinary Dermatology
|October 14, 2021
PubMed

Insights

Enrofloxacin effectively treats canine bacterial pyoderma in 93.3% of dogs. Extended treatment durations beyond manufacturer recommendations are necessary to prevent relapses in some cases.

Area of Science:

  • Veterinary Medicine
  • Pharmacology

Background:

  • Bacterial pyoderma is a common skin infection in dogs.
  • Enrofloxacin is a fluoroquinolone antibiotic used in veterinary medicine.

Purpose of the Study:

  • To evaluate the efficacy and safety of enrofloxacin for treating canine bacterial pyoderma.
  • To determine optimal treatment duration for enrofloxacin in canine pyoderma.

Main Methods:

  • Thirty dogs diagnosed with bacterial pyoderma were treated with oral enrofloxacin (2.5 mg/kg every 12 hours).
  • Treatment duration ranged from 2 to 14 weeks.
  • Dogs were re-examined post-treatment, with follow-up periods of 1 to 4 months.

Main Results:

  • An excellent treatment response was observed in 93.3% of dogs (28 out of 30).
  • Relapses occurred in 25% of dogs within 1 to 4 months post-treatment.
  • Only one dog experienced minor side effects.

Conclusions:

  • Enrofloxacin is a highly effective antibiotic for canine bacterial pyoderma.
  • Treatment durations longer than currently recommended by manufacturers may be required for sustained efficacy.
  • Further research into optimal enrofloxacin dosing and duration for canine pyoderma is warranted.

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