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Related Experiment Video

Updated: Oct 17, 2025

Author Spotlight: Evaluation of Lipid Droplet Size and Fusion in Bovine Hepatic Cells
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Follicular lipidosis in three Rottweilers.

Thelma Lee Gross1, Aurea Pascal-Tenorio2, Robert J Munn3

  • 1California Dermatopathology Service and Consolidated Veterinary Diagnostics, West Sacramento, CA 95605-1600, USA.

Veterinary Dermatology
|October 14, 2021
PubMed
Summary
This summary is machine-generated.

Follicular lipidosis, a newly reported condition in Rottweilers, causes hair loss due to lipid accumulation in hair matrix cells. This study details three cases, noting concurrent health issues in one dog.

Keywords:
Rottweileralopeciadogfollicular diseasehair folliclelipidosis

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Area of Science:

  • Veterinary Dermatology
  • Canine Pathology
  • Dermatohistopathology

Background:

  • Follicular lipidosis is a newly identified condition affecting hair follicles.
  • This report details the first known cases in three young Rottweilers.

Observation:

  • Three Rottweilers presented with hypotrichosis (hair loss) on the face and feet, with one exhibiting dulling and lightening of other hair.
  • Hair matrix cells were found to be swollen with intracellular lipid.
  • One dog showed poor growth, elevated kidney values (blood urea nitrogen and creatinine), small thyroid glands, and chronic renal disease.

Findings:

  • Histopathological examination confirmed intracellular lipid accumulation within hair matrix cells.
  • Electron microscopy and oil-red-O staining identified the lipid deposits.
  • Two dogs showed partial or complete resolution of hair loss over time, with one retaining mild histological changes.

Implications:

  • This is the first documented report of follicular lipidosis in any species.
  • Understanding this condition is crucial for accurate diagnosis and management of hair loss in dogs.
  • Further research may elucidate the underlying causes and potential treatments for follicular lipidosis.