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Calcinosis circumscripta and renal dysplasia in a dog
1California Dermatopathology Service and Consolidated Veterinary Diagnostics, West Sacramento, CA, USA.
Veterinary Dermatology
|October 14, 2021
Summary
This study reports a case of calcinosis circumscripta in a young Lhasa Apso, linked to renal dysplasia. The condition manifested as paw pad lesions, likely due to metastatic calcification in renal failure.
Area of Science:
- Veterinary Dermatology
- Canine Pathology
- Nephrology
Background:
- Calcinosis circumscripta is a rare condition characterized by calcium deposits in soft tissues.
- Renal dysplasia is a congenital disorder affecting kidney development.
- Concurrent renal failure and hypercalcemia can predispose to metastatic calcification.
Observation:
- A young Lhasa Apso presented with lameness due to calcinosis circumscripta affecting the metatarsal and metacarpal paw pads.
- Serum chemistry revealed renal failure with concurrent hypercalcemia and hyperphosphatemia.
- Post-mortem examination confirmed renal dysplasia.
Findings:
- Calcinosis circumscripta in this case was likely a manifestation of metastatic calcification secondary to renal failure.
- The paw pad involvement may have been exacerbated by conformational stresses leading to tissue damage.
- This is the first reported instance of calcinosis circumscripta associated with canine renal dysplasia.
Implications:
- This case highlights a potential link between renal dysplasia and soft tissue calcification in dogs.
- Understanding this association may aid in earlier diagnosis and management of similar cases.
- Further research is warranted to elucidate the pathomechanisms involved in this condition.
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