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Exosomal CD63 in critically ill patients with sepsis
Yunjoo Im1, Hongseok Yoo1, Ryoung-Eun Ko2
1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Republic of Korea.
Scientific Reports
|October 14, 2021
Summary
Elevated exosomal CD63 levels in sepsis patients correlate with organ failure severity. Higher CD63 concentrations predict increased mortality risk in critically ill individuals with sepsis.
Area of Science:
- Immunology
- Biochemistry
- Critical Care Medicine
Background:
- CD63 is a tetraspanin protein found on exosomes, involved in immune cell signaling.
- Sepsis involves immunometabolic dysfunction and organ failure.
- The role of exosomal CD63 in sepsis severity and mortality is not well understood.
Purpose of the Study:
- To investigate the association between exosomal CD63 levels and sepsis severity.
- To determine if exosomal CD63 can predict mortality in sepsis patients.
Main Methods:
- Exosomal CD63 was quantified in plasma from 217 sepsis patients and 20 healthy controls using ELISA.
- Correlation with Sequential Organ Failure Assessment (SOFA) scores was assessed.
- Mortality prediction was evaluated using Youden's index and Kaplan-Meier survival analysis.
Main Results:
- Exosomal CD63 levels were significantly higher in sepsis and septic shock groups compared to controls.
- A positive correlation was found between exosomal CD63 levels and SOFA scores.
- Elevated exosomal CD63 (>126 µg/mL) was associated with increased 28-day, in-hospital, and 90-day mortality.
Conclusions:
- Exosomal CD63 levels are elevated in sepsis and correlate with disease severity.
- Exosomal CD63 serves as a potential biomarker for predicting mortality in critically ill sepsis patients.
