Cell-Based Transplantation versus Cell Homing Approaches for Pulp-Dentin Complex Regeneration
Geraldine M Ahmed1,2, Eman A Abouauf1,3, Nermeen AbuBakr1,4
1Stem Cell and Tissue Engineering Research Group, Faculty of Dentistry, Cairo University, Cairo, Egypt.
Stem Cells International
|October 14, 2021
Summary
Regenerative dentistry offers new hope for damaged dental tissues. This review explores cell-based and cell homing therapies for regenerating the pulp-dentin complex, crucial for dental health.
Area of Science:
- Dental Science
- Regenerative Medicine
- Biomaterials
Background:
- Pulp vitality loss, due to caries, trauma, or chemical damage, is a significant global health issue.
- Regenerative dentistry aims to restore damaged dental tissues, particularly the pulp-dentin complex.
Purpose of the Study:
- To review and elaborate on two primary regenerative therapies for irreversibly inflamed or necrotic pulp.
- To compare cell-based (transplantation) and cell homing (revascularization/in situ/intravenous stem cell injection) approaches.
Main Methods:
- Literature review of existing studies on regenerative endodontic therapies.
- Analysis of the advantages and drawbacks of cell-based and cell homing techniques in clinical settings.
Main Results:
- Both cell-based and cell homing therapies show promise for pulp-dentin complex regeneration.
- Each approach presents unique benefits and challenges for clinical implementation.
Conclusions:
- Further research and clinical refinement are needed to optimize these regenerative strategies.
- Successful regeneration of a fully functional pulp-dentin complex remains the ultimate goal.
