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ROS Signaling-Mediated Novel Biological Targets: Brf1 and RNA Pol III Genes

Liling Zheng1, Yongluan Lin2, Shuping Zhong2

  • 1First Hospital of Quanzhou Affiliated to Fujian Medical University, China.

Oxidative Medicine and Cellular Longevity
|October 14, 2021
PubMed

Insights

Reactive oxygen species (ROS) are implicated in cell damage and disease. Our research reveals that Brf1 and RNA Pol III genes are new targets of ROS, linking them to cancer development.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cellular Biology

Background:

  • Biomolecule metabolism generates reactive oxygen species (ROS) under both normal and disease states.
  • Dietary factors and carcinogens can increase ROS production, leading to cellular stress and tissue injury.
  • Protein metabolism, regulated by Brf1 (transcription factor II B-related factor 1) and RNA Pol III genes, is vital for cellular function.

Purpose of the Study:

  • To investigate the signaling pathways mediating the deregulation of Brf1 and RNA Pol III genes.
  • To explore the link between ROS, Brf1, and RNA Pol III gene transcription in the context of cell proliferation and cancer.
  • To summarize recent findings on signaling events impacting Brf1 and RNA Pol III gene transcription.

Main Methods:

  • Review of studies focusing on signaling events.
  • Analysis of the relationship between ROS, Brf1, and RNA Pol III genes.
  • Investigation of the role of alcohol, EGF, DEN, and MNNG in gene deregulation.

Main Results:

  • Deregulation of Brf1 and RNA Pol III genes is associated with cell proliferation, transformation, tumor development, and human cancers.
  • Alcohol, EGF, DEN, and MNNG induce deregulation of Brf1 and RNA Pol III genes via distinct signaling pathways.
  • Brf1 and RNA Pol III genes are identified as novel biological targets of ROS.

Conclusions:

  • Signaling events play a crucial role in mediating the deregulation of Brf1 and RNA Pol III gene transcription.
  • Brf1 and RNA Pol III genes represent important targets for understanding ROS-induced cellular damage and disease.
  • Further research into these signaling pathways could reveal new therapeutic strategies for ROS-related disorders and cancers.

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