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[Clinical evaluation of imipenem/cilastatin sodium in the pediatric field]
The Japanese Journal of Antibiotics
|July 1, 1986
Insights
Imipenem/cilastatin sodium demonstrated 100% clinical efficacy in pediatric infections. This antibiotic showed a favorable safety profile, with only minor, transient side effects in one patient, suggesting it is a safe and effective treatment option.
Area of Science:
- Infectious Diseases
- Pediatric Medicine
- Pharmacology
Background:
- Pediatric infections require effective and safe antimicrobial agents.
- Carbapenem antibiotics offer broad-spectrum activity.
- Imipenem/cilastatin sodium is a combination antibiotic with established efficacy.
Purpose of the Study:
- To evaluate the safety and efficacy of imipenem/cilastatin sodium (MK-0787/MK-0791) in pediatric patients.
- To assess the clinical outcomes and adverse events associated with this antibiotic in a pediatric population.
Main Methods:
- A clinical study involving 7 pediatric patients with infections.
- Administration of imipenem/cilastatin sodium (MK-0787/MK-0791).
- Monitoring for clinical efficacy and adverse events.
Main Results:
- Achieved a 100% clinical efficacy ratio in the treated pediatric patients.
- Observed a favorable safety profile with no significant side effects.
- Transient elevations in S-GOT, S-GPT, and eosinophilia were noted in only one patient.
Conclusions:
- Imipenem/cilastatin sodium (MK-0787/MK-0791) is a safe and effective antibiotic for treating pediatric infections.
- The antibiotic demonstrated excellent clinical outcomes with minimal adverse events.
- Further investigation may support its broader use in pediatric infectious disease management.
Abstract:
Imipenem/cilastatin sodium (MK-0787/MK-0791) was evaluated for its safety and efficacy in 7 pediatric patients with infections. The clinical efficacy ratio was 100 percent. No side effect was observed except for elevations of S-GOT and S-GPT and eosinophilia in 1 patient. It may be considered that MK-0787/MK-0791 is a safe and useful antibiotic for the treatment of pediatric infections.