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Related Experiment Video

Updated: Oct 16, 2025

Imaging Ca2+ Responses During Shigella Infection of Epithelial Cells

Imaging Ca2+ Responses During Shigella Infection of Epithelial Cells

Published on: May 24, 2018

Shigella shuts down the pyrop-technic show.

Cristina Giogha¹, Jaclyn S Pearson²

¹Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria, Australia; Department of Molecular and Translational Science, Monash University, Clayton, Victoria, Australia.

Cell Host & Microbe

|October 14, 2021

Summary

This summary is machine-generated.

Shigella bacteria infect humans but not mice. Researchers found Shigella degrades Gasdermin D, a protein that triggers cell death, to overcome this natural resistance and infect human cells.

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Area of Science:

Microbiology
Immunology
Cell Biology

Background:

Shigella is a significant human pathogen responsible for infectious diarrhea.
Mice exhibit natural resistance to Shigella infection, posing a challenge for studying pathogenesis.
Understanding host-pathogen interactions is crucial for developing effective treatments.

Purpose of the Study:

To elucidate the molecular mechanisms underlying Shigella's species-specific infectivity.
To investigate how Shigella overcomes host defense mechanisms in susceptible species.

Main Methods:

The study involved analyzing Shigella's interaction with host cell proteins.
Experiments focused on the role of Gasdermin D in host defense against Shigella.

Main Results:

Shigella actively targets and degrades the host protein Gasdermin D.
Degradation of Gasdermin D prevents pyroptosis, a programmed cell death pathway.
This evasion mechanism allows Shigella to successfully infect human cells.

Conclusions:

Shigella employs a sophisticated strategy to subvert host immunity.
Targeting Gasdermin D is a key mechanism for Shigella pathogenesis in humans.
This finding offers potential targets for novel anti-Shigella therapies.