Related Experiment Video
Updated: Oct 16, 2025

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
Published on: May 2, 2025
Effect of Ramadan fasting on renal function of people with diabetes; a prospective longitudinal study
Sarwat Anjum1, Sanobia Yousuf2, Muhammad Yakoob Ahmedani3
1Endocrine fellow, Department of Endocrine, Baqai Institute of Diabetology and Endocrinology, Baqai Medical University, Karachi - Pakistan.
Aim:
To observe the effect of Ramadan fasting on renal function of people with diabetes.
Methods:
This prospective, observational, and longitudinal study was conducted at Baqai Institute of Diabetology and Endocrinology, between April-July 2019. People with type2 diabetes mellitus were recruited using convenient sampling. Demographic data along with renal function were recorded before Ramadan. Kidney functions were assessed in those who came for follow up at 6 weeks, 3 months, and a year after Ramadan.
Results:
A total of seventy people with diabetes participated in this study with the mean age of 53.11 ± 8.70 years. A significant decline in eGFR was noted around six weeks post Ramadan with a significant improvement of eGFR at 3 months follow-up. The normalization of kidney functions among the study participants was observed even after one year of Ramadan.
Conclusion:
In this study post Ramadan assessment of creatinine clearance showed a significant fall among fasting people with diabetes though remained with in normal limits. Significant improvement and reversal of kidney functions was noted in those who followed within three months' time.
Related Concept Videos
Factors Affecting Renal Clearance: Renal Impairment
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
Diabetes: Symptoms, Diagnosis, and Complications
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration
Serum Studies: Renal Function Tests
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion
Renal Failure: Dose Adjustments
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...

