Clinical and experimental observations on resinifying therapy

Area of Science:

• Endodontics
• Dental Materials Science

Background:

• Resinifying therapy offers a novel approach to endodontic treatment.
• Understanding the properties and clinical efficacy of resinifying agents is crucial.

Purpose of the Study:

• To describe the principles, indications, and techniques of resinifying therapy.
• To evaluate the properties and clinical outcomes of a specific resinifying agent.

Main Methods:

• Assessed agent permeability, bacteriostasis, and volumetric changes.
• Utilized 14C-labeled phenoaldehyde to track agent infiltration into dentinal tubules.
• Determined antimicrobial activity post-polymerization and in vivo sealing maintenance.
• Conducted a clinical follow-up of 78 teeth in 69 patients with pulpoperiapical diseases.

Main Results:

• The resinifying agent infiltrated main and accessory canals, as well as dentinal tubules.
• In vivo, the agent maintained canal sealing without volume change for up to 9 months.
• Achieved an 82.05% success rate in treating pulpoperiapical diseases over 6-12 months.
• Histological analysis showed mild/no inflammation in 85.7% and healing in 53.6% of treated specimens.

Conclusions:

• Resinifying therapy demonstrates significant potential for endodontic treatment.
• The evaluated agent provides effective canal obturation, long-term sealing, and antimicrobial activity.
• The therapy shows promising clinical success rates and favorable tissue response.