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Updated: Oct 16, 2025

A Preclinical Model of Exertional Heat Stroke in Mice
Published on: July 1, 2021
Exertional heat stroke with reversible severe cerebral edema
1Department of Neurology, Chungbuk National University College of Medicine, Cheongju, Korea.
Abstract:
Severe cerebral edema associated with exertional heat stroke is a major cause of death or disability. However, few studies on severe cerebral edema resulting from heat stroke have reported neuroradiological findings. Moreover, all the patients in these previous reports either died or remained severely disabled. Here, we report a case of exertional heat stroke with severe cerebral edema that probably developed or worsened due to delayed body temperature normalization. In contrast to previous reports, the patient showed complete clinical and neuroradiological recovery. This rare case suggests that severe cerebral edema could be reversed through meticulous supportive management. Moreover, it confirms the importance of rapid and effective cooling in heat stroke treatment.
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