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Updated: Oct 16, 2025

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane

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Wilms tumour.

Filippo Spreafico¹, Conrad V Fernandez², Jesper Brok³

¹Department of Medical Oncology and Hematology, Paediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. filippo.spreafico@istitutotumori.mi.it.

Nature Reviews. Disease Primers

|October 15, 2021

Summary

This summary is machine-generated.

Wilms tumour (WT) is a childhood kidney cancer linked to disrupted organ development. While 90% of children can be cured, disparities in outcomes and slower adoption of targeted therapies necessitate further research.

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Longitudinal Intravital Imaging of Brain Tumor Cell Behavior in Response to an Invasive Surgical Biopsy

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Area of Science:

Pediatric Oncology
Developmental Biology
Cancer Genetics

Background:

Wilms tumour (WT) is a childhood embryonal cancer arising from disrupted nephrogenesis.
Key genes critical for kidney development are implicated in WT pathogenesis.
Despite high cure rates, survival disparities persist globally.

Purpose of the Study:

To highlight the intersection of organogenesis and tumorigenesis in WT.
To emphasize the need for improved understanding and targeting of WT development pathways.
To address disparities in outcomes and the slow integration of biology-driven approaches.

Main Methods:

Review of decades of clinical and basic research in WT.
Analysis of updated epidemiological data on WT incidence.
Examination of current prognostic classifications incorporating molecular alterations.

Main Results:

Curative therapy is achievable in 90% of pediatric WT cases, including disseminated disease.
Global incidence variations and survival disparities are evident.
Biology-driven risk stratification and drug development lag behind other childhood cancers.

Conclusions:

Advances in understanding WT genes and pathways are crucial for improving patient outcomes.
Current treatment involves chemotherapy, surgery, and sometimes radiation.
Future research should focus on advanced imaging, optimized radiotherapy, and novel surgical techniques.