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Primary Biliary Cholangitis: A Case of Underdiagnosis
Sofia Garcês Soares1, Marina Mendes1, Sofia Rodrigues Carvalho1
1Internal Medicine, Centro Hospitalar Tâmega e Sousa, Penafiel, PRT.
Cureus
|October 15, 2021
Summary
Primary biliary cholangitis is a rare autoimmune liver disease. Early diagnosis and treatment can prevent progression to cirrhosis and liver failure.
Area of Science:
- Hepatology
- Autoimmune Diseases
- Cholestatic Liver Disease
Background:
- Primary biliary cholangitis (PBC) is a rare, autoimmune cholestatic liver disease.
- It predominantly affects women and can lead to liver cirrhosis.
- The exact causes (etiopathogenesis) of PBC are not fully understood.
Observation:
- A case of a 63-year-old woman with a decade-long history of cytocholestasis is presented.
- The patient had no prior history of using hepatotoxic drugs.
- This case highlights a prolonged analytical pattern suggestive of PBC.
Findings:
- The patient exhibited a persistent analytical pattern of cytocholestasis.
- The clinical course spanned over ten years.
- This presentation occurred in the absence of known drug-induced liver injury.
Implications:
- This case underscores the importance of recognizing prolonged cytocholestasis patterns.
- Early identification of primary biliary cholangitis is crucial for management.
- Timely intervention can potentially halt disease progression to advanced liver disease.
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