[Research progress of interfacial tissue engineering in rotator cuff repair]

Area of Science:

• Biomedical Engineering
• Regenerative Medicine
• Orthopedic Surgery

Background:

• Rotator cuff injuries are common, leading to pain and disability.
• Current treatments have limitations in fully restoring function.
• Interfacial tissue engineering offers a promising approach for tendon-to-bone healing.

Purpose of the Study:

• To review and summarize the research progress in interfacial tissue engineering for rotator cuff repair.
• To identify key components and strategies employed in this field.
• To highlight challenges and future directions.

Main Methods:

• Comprehensive literature review of domestic and international research.
• Analysis of studies focusing on interfacial tissue engineering for rotator cuff repair.
• Synthesis of findings on critical elements involved in the repair process.

Main Results:

• Interfacial tissue engineering aims to reconstruct hierarchical tissues for damaged joint repair.
• Key elements in rotator cuff repair include seed cells, growth factors, biomaterials, oxygen concentration, and mechanical stimulation.
• Gradient biomaterials combined with cellular and biochemical cues show potential.

Conclusions:

• Optimal rotator cuff healing requires gradient biomaterials, seed cells, growth factors, and controlled culture conditions (oxygen, mechanical stimulation).
• The combination of these elements is crucial for effective regeneration.
• Clinical translation of these advanced treatments is progressing slowly but holds significant promise.