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GDM-complicated pregnancies: focus on adipokines
Marta Mallardo1,2, Sara Ferraro2,3, Aurora Daniele2,4
1Dipartimento di Scienze e Tecnologie Ambientali Biologiche Farmaceutiche, Università degli Studi della Campania "Luigi Vanvitelli", Via G. Vivaldi 42, 81100, Caserta, Italy.
Gestational diabetes mellitus (GDM) involves pregnancy glucose intolerance, often linked to insulin resistance. This review explores how adipokines like adiponectin and leptin may contribute to GDM development and progression.
Area of Science:
- Obstetrics and Gynecology
- Endocrinology
- Metabolic Disorders
Background:
- Gestational diabetes mellitus (GDM) is a pregnancy complication characterized by glucose intolerance.
- Its exact pathophysiology is unclear, but insulin resistance and pancreatic beta-cell dysfunction are key factors.
- Pregnancy involves significant metabolic adaptations crucial for fetal growth and maternal health.
Purpose of the Study:
- To review the current understanding of adipokines' roles in GDM.
- To examine the involvement of specific adipokines in GDM pathogenesis and prognosis.
Main Methods:
- Literature review focusing on adipokines and GDM.
- Analysis of studies investigating adipokine dysregulation in pregnancy.
Main Results:
- Adipokines are adipose tissue-derived hormones with significant metabolic influence.
- Adiponectin, leptin, visfatin, resistin, and TNF-α are frequently dysregulated in GDM.
- These adipokines may hold pathological and prognostic significance in GDM.
Conclusions:
- Adipokines play a crucial role in the development and progression of GDM.
- Further research into adipokine function can enhance understanding and management of GDM.
- Dysregulated adipokines represent potential biomarkers for GDM risk and severity.
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