Acute Resistance Exercise Temporarily Reduces Circulating Adiponectin in Trained Young Men: A Pilot Study.

Area of Science:

• Exercise Physiology
• Endocrinology
• Sports Science

Background:

• Adiponectin is an adipokine with crucial roles in metabolic adaptation, insulin sensitivity, and anti-inflammatory processes.
• While its regulation post-resistance exercise is known, short-term changes and links to muscle damage markers require further investigation.

Purpose of the Study:

• To investigate the acute modulation of plasma and salivary adiponectin following resistance exercise.
• To examine the correlation between adiponectin changes and muscle damage markers (creatine kinase) after resistance training.

Main Methods:

• Nine resistance-trained men performed two total-body resistance exercise sessions with varying time under tension (TUT).
• Plasma and saliva samples were collected pre-exercise and at 15 min, 24 h, and 48 h post-exercise.
• Plasma adiponectin, creatine kinase (CK), and muscle soreness (VAS) were measured.

Main Results:

• Plasma adiponectin significantly decreased from baseline to 48 h post-exercise in both high and moderate TUT conditions.
• Salivary adiponectin levels remained unchanged throughout the study period.
• A significant increase in CK and a decrease in adiponectin were observed, but no significant linear correlation was found between CK elevation and adiponectin reduction.

Conclusions:

• Acute resistance exercise induces a time-dependent decrease in circulating adiponectin, independent of TUT.
• Adiponectin serves as a marker for acute metabolic adaptation to resistance exercise.
• The dissociation between adiponectin and muscle damage markers suggests distinct regulatory pathways, and saliva is not a reliable indicator of plasma adiponectin changes.