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[Psoriasis and bullous dermatoses].

G Stüttgen, H Bockendahl, W Remy

    Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete
    |March 1, 1978
    PubMed
    Summary
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    Psoriasis vulgaris patients in Berlin developed pemphigoid-type bullous eruptions after sun exposure or treatments like photochemotherapy. These reactions, potentially linked to subclinical pemphigoid, highlight treatment risks.

    Area of Science:

    • Dermatology
    • Immunodermatology

    Background:

    • Psoriasis vulgaris is a chronic inflammatory skin condition.
    • Bullous dermatoses, such as bullous pemphigoid, are autoimmune blistering diseases.

    Observation:

    • Seven cases of psoriasis vulgaris co-occurring with bullous eruptions of the pemphigoid type were observed in Berlin over five years.
    • Exogenous factors including sun exposure, photochemotherapy, and dithranol treatment precipitated these bullous eruptions.
    • Immunofluorescence confirmed the pemphigoid nature of the eruptions, ruling out Type IV contact allergy.

    Findings:

    • The pemphigoid eruptions were triggered by specific external factors in psoriasis patients.
    • Two cases exhibited elevated eosinophil counts in both tissue and blood.
    • These findings align with previous research suggesting treatment can unmask subclinical pemphigoid.

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    Implications:

    • Clinicians should be aware of the potential for pemphigoid-type eruptions in psoriasis patients undergoing certain treatments.
    • Further research is needed to elucidate the mechanisms linking psoriasis treatments to bullous pemphigoid development.
    • Monitoring for blistering conditions is crucial in psoriasis patients exposed to photosensitizing agents or specific therapies.