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Bridging the Gap: A Geroscience Primer for Neuroscientists With Potential Collaborative Applications.

Jessica M Hoffman¹, Caesar M Hernandez², Abbi R Hernandez³

¹Department of Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA.

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

|October 15, 2021

Summary

Geroscience, the study of aging, offers valuable insights for neuroscience in understanding age-related neurodegenerative diseases. Bridging these fields can enhance research efficiency and translational potential.

Keywords:

Cognitive decline Frailty Life-span–extending interventions Resilience

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Area of Science:

Gerontology and Neuroscience
Interdisciplinary Research

Background:

Neurodegenerative diseases disproportionately affect older individuals.
A gap exists between aging research (geroscience) and neurodegenerative disease research (neuroscience).

Purpose of the Study:

To review the current state of geroscience.
To explore the benefits of geroscience principles for neuroscience.
To identify and address the disconnects between geroscience and neuroscience.

Main Methods:

Literature review of geroscience.
Analysis of interdisciplinary collaboration potential.
Discussion of research gaps and solutions.

Main Results:

Geroscience provides theories applicable to age-related neurological conditions.
Enhanced collaboration can improve research efficiency and translational outcomes.
Specific "missing links" between the fields were identified.

Conclusions:

Integrating geroscience and neuroscience is crucial for advancing the study of neurodegenerative diseases.
Fostering collaboration will lead to more effective and reproducible research.
Bridging these fields holds significant translational potential for treating age-related brain disorders.