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Updated: Oct 16, 2025

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
11:17

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

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Indications for medical antibiotic prophylaxis and potential targets for antimicrobial stewardship intervention: a

Petros Ioannou1, Stamatis Karakonstantis1, Jeroen Schouten2

  • 1Department of Internal Medicine & Infectious Diseases, University Hospital of Heraklion, Heraklion, Crete, Greece.

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
|October 15, 2021
PubMed
Abstract

Insights

Antimicrobial stewardship (AMS) interventions for medical antibiotic prophylaxis (AP) in adults are needed. This review identifies targets to optimize AP use, including antibiotic-sparing strategies and appropriate duration.

Area of Science:

  • Infectious Diseases
  • Pharmacology
  • Public Health

Background:

  • Antimicrobial stewardship (AMS) literature primarily focuses on infection treatment and surgical prophylaxis.
  • The role of AMS in medical antibiotic prophylaxis (AP) remains underexplored.

Purpose of the Study:

  • To identify key targets for AMS interventions specifically for medical AP in adult patients.

Main Methods:

  • PubMed database was searched for relevant literature.
  • Practice guidelines and evidence were reviewed to identify indications for medical AP.

Main Results:

  • Potential AMS intervention targets include: optimizing antibiotic-sparing strategies, reducing unnecessary AP, narrowing antibiotic spectrum, shortening AP duration, evaluating antibiotic cycling, and addressing research gaps.
  • Specific areas for intervention include recurrent infections, acute pancreatitis, bite wounds, and catheter manipulations.

Conclusions:

  • Current trends in AP are summarized.
  • Specific targets for AMS interventions in medical AP are proposed to improve antimicrobial use and combat resistance.
Keywords:
Antibiotic prophylaxisAntimicrobial resistanceAntimicrobial stewardshipDrug resistanceMicrobial

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