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Updated: Oct 16, 2025

An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
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Immunotherapy in multiple myeloma

Yamna Jadoon1, Mustaqeem A Siddiqui2

  • 1Division of Hematology, Mayo Clinic, Rochester MN, United States of America.

Cancer Treatment and Research Communications
|October 15, 2021
PubMed

Despite available therapies, Multiple Myeloma (MM) remains an incurable hematologic malignancy. Over the past three decades, there have been tremendous developments in therapeutic options for MM. In regards to immunotherapy, Daratumumab was the first monoclonal antibody to receive FDA approval for multiple myeloma. Since then, other monoclonal antibodies such as elotuzumab and isatuximab have received FDA approval. Many clinical trials are underway investigating the efficacy of newer immunotherapies. This review summarizes recently presented and/or published data regarding this growing field, specifically regarding monoclonal antibodies, antibody-drug conjugates, bispecific antibodies, and trispecific antibodies.

Keywords:
Antibody drug conjugatesBispecific antibodiesImmunotherapyMonoclonal antibodiesMultiple myelomaTrispecific antibodies

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