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Updated: Oct 16, 2025

Generation of Self-assembled Vascularized Human Skin Equivalents
Published on: February 12, 2021
Vitamin E supplementation in inflammatory skin diseases
Enzo Berardesca1, Norma Cameli2
1Phillip Frost Department of Dermatology, University of Miami, Miami, Florida, USA.
Abstract:
Vitamin E is a powerful lipophilic antioxidant that protects membranes from lipid peroxidation, and consequently, oxidative damage. Oxidative stress plays a role in the development of neurodegenerative diseases. Vitamin E supplementation is recommended in patients with vitamin E deficiency due to fat malabsorption. The addition of vitamin E to the diet slows Alzheimer's disease progression and protects older patients against respiratory infections. Recent studies also point to the involvement of oxidative stress in the pathology of immune-mediated skin diseases, such as atopic dermatitis and psoriasis. We reviewed the available clinical trials that investigated the role of vitamin E supplementation in preventing and treating atopic dermatitis and psoriasis. Data from these studies point to a positive role of vitamin E supplementation in these diseases. Still, due to limitations in study design, further evidence is needed to reach a definite conclusion.
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