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Vitamin E supplementation in inflammatory skin diseases
Enzo Berardesca1, Norma Cameli2
1Phillip Frost Department of Dermatology, University of Miami, Miami, Florida, USA.
Dermatologic Therapy
|October 16, 2021
Summary
Vitamin E, a potent antioxidant, shows promise in managing neurodegenerative and immune-mediated skin diseases like psoriasis and atopic dermatitis. Further research is needed to confirm its therapeutic benefits due to study limitations.
Area of Science:
- Nutritional Science
- Dermatology
- Neuroscience
Background:
- Vitamin E is a lipophilic antioxidant crucial for protecting cell membranes against oxidative damage.
- Oxidative stress is implicated in neurodegenerative diseases and immune-mediated skin conditions like atopic dermatitis and psoriasis.
- Vitamin E deficiency, often due to fat malabsorption, necessitates supplementation.
Purpose of the Study:
- To review clinical trials on vitamin E supplementation for preventing and treating atopic dermatitis and psoriasis.
- To evaluate the role of vitamin E in managing oxidative stress-related diseases.
Main Methods:
- Systematic review of clinical trials investigating vitamin E supplementation.
- Analysis of studies focusing on atopic dermatitis and psoriasis patients.
Main Results:
- Clinical trial data suggest a beneficial role for vitamin E supplementation in atopic dermatitis and psoriasis.
- Vitamin E supplementation may slow Alzheimer's disease progression and protect against respiratory infections in older adults.
Conclusions:
- Vitamin E supplementation appears to have a positive impact on immune-mediated skin diseases.
- Further high-quality clinical trials are required to establish definitive conclusions regarding vitamin E's efficacy in these conditions.
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