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Ventriculo-arterial coupling in patients with stable ischemic heart disease undergoing percutaneous coronary

Hung Tran Duc1, Ha Pham Vu Thu1, Vien T Truong2

  • 1Department of Cardiology, Military Hospital 103, Vietnam Military Medical University, Hanoi, Vietnam.

The International Journal of Cardiovascular Imaging
|October 16, 2021
PubMed

Insights

Ventriculo-arterial coupling (VAC) was significantly improved in patients with stable ischemic heart disease (SIHD) six months after percutaneous coronary intervention (PCI). This enhancement in VAC may explain the benefits of PCI for SIHD patients.

Area of Science:

  • Cardiology
  • Cardiovascular Physiology
  • Interventional Cardiology

Background:

  • Stable ischemic heart disease (SIHD) affects cardiovascular function.
  • Ventriculo-arterial coupling (VAC) describes the relationship between the left ventricle and the arterial system.
  • Understanding VAC in SIHD and its response to intervention is crucial.

Purpose of the Study:

  • To investigate ventriculo-arterial coupling (VAC) and its components (arterial elastance [Ea], end-systolic elastance [Ees]) in patients with SIHD.
  • To assess changes in VAC following percutaneous coronary intervention (PCI).

Main Methods:

  • Echocardiography was used to calculate VAC, Ea, and Ees in 129 SIHD patients undergoing PCI and 40 controls.
  • Measurements were taken at baseline and at 1, 3, and 6 months post-PCI.
  • Linear mixed-effects models analyzed the impact of PCI on VAC parameters over 6 months.

Main Results:

  • SIHD patients had lower Ees and higher VAC compared to controls (p < 0.05).
  • Following PCI, Ees (p = 0.01) and VAC (p < 0.001) significantly improved over 6 months.
  • The extent of VAC improvement correlated with the stented artery.

Conclusions:

  • Ventriculo-arterial coupling (VAC) is significantly altered in SIHD patients.
  • PCI leads to significant improvements in VAC and its components in SIHD patients.
  • VAC may serve as a feasible parameter for assessing SIHD and understanding PCI benefits.

Keywords:
Percutaneous coronary interventionStable ischemic heart diseaseVentricular arterial coupling

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