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Published on: December 2, 2015
Multivariate alterations in insula - Medial prefrontal cortex linked to genetics in 12q24 in schizophrenia
Wenhao Jiang1, Kelly Rootes-Murdy2, Jiayu Chen3
1Department of Psychology, Georgia State University, United States of America; Department of Psychosomatics and Psychiatry, Zhongda Hospital, Institute of Psychosomatics, Medical School, Southeast University, Nanjing, China.
Abstract:
The direct effect of genetic variations on clinical phenotypes within schizophrenia (SZ) remains elusive. We examined the previously identified association of reduced gray matter concentration in the insula - medial prefrontal cortex and a quantitative trait locus located in 12q24 in a SZ dataset. The main analysis was performed on 1461 SNPs and 830 participants. The highest contributing SNPs were localized in five genes including TMEM119, which encodes a microglial marker, that is associated with neuroinflammation and Alzheimer's disease. The gene set in 12q4 may partially explain brain alterations in SZ, but they may also relate to other psychiatric and developmental disorders.
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