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Cardiovascular Events During and After Bronchiectasis Exacerbations and Long-term Mortality
Raúl Méndez1, Laura Feced2, Victoria Alcaraz-Serrano3
1Pneumology Department, La Fe University and Polytechnic Hospital, Valencia, Spain; Respiratory Infections Research Group, Health Research Institute La Fe, Valencia, Spain.
Chest
|October 17, 2021
Summary
Cardiovascular events (CVE) risk increases after bronchiectasis exacerbations. Age, hypertension, COPD, and severe exacerbations are key risk factors, worsening long-term prognosis and mortality.
Area of Science:
- Pulmonary Medicine
- Cardiology
- Epidemiology
Background:
- Bronchiectasis exacerbations are linked to increased cardiovascular event (CVE) risk.
- Previous studies indicate higher incidence of arrhythmias, ischemic episodes, and heart failure post-exacerbation.
Purpose of the Study:
- To identify risk factors for CVE during and after bronchiectasis exacerbations.
- To assess the impact of CVE on mortality in bronchiectasis patients.
Main Methods:
- Retrospective analysis of a prospective observational study involving 250 bronchiectasis patients.
- Data collected included demographics, comorbidities, and exacerbation severity.
- Semi-competing risks model used to analyze risk factors for CVE and mortality.
Main Results:
- During a median 35-month follow-up, 29.6% of patients experienced CVE, and 37.2% died.
- Significant risk factors for CVE included older age, arterial hypertension, COPD, and severe exacerbations.
- Patients with CVE exhibited higher mortality rates compared to those without.
Conclusions:
- Demographic factors and comorbidities are significant predictors of CVE following bronchiectasis exacerbations.
- The occurrence of CVE adversely affects the long-term prognosis and survival of bronchiectasis patients.
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