1,25-dihydroxyvitamin D and cardiometabolic risk in healthy sedentary adults: The FIT-AGEING study

A growing body of scientific works investigating the physio-pathological mechanisms behind cardiovascular disease has suggested that vitamin D deficiency could play a key role on its development. However, it remains unclear whether its active form (1,25-dihydroxyvitamin D [1,25(OH)₂D] is associated with cardiometabolic risk factors in healthy individuals. The aim of the present study was to investigate the relationships of 1,25(OH)₂D plasma levels with cardiometabolic risk factors in a sample of healthy sedentary adults.

A total of 73 adults (~53% women; 54 ± 5 years old) were included in the current cross-sectional study. A sex-specific cardiometabolic risk score (MetScore) was calculated for each subject based on clinical parameters (i.e., waist circumference, systolic and diastolic blood pressure, plasma glucose, high-density lipoprotein cholesterol, and triglycerides) according to the International Diabetes Federation's clinical criteria. Plasma levels of 1,25(OH)₂D were measured using a DiaSorin Liaison® immunochemiluminometric analyzer.

No significant association was detected between 1,25(OH)₂D and MetScore (β = 0.037, R² = 0.001, p = 0.77), independently of age, sex and fat body mass index. A significant inverse association were observed between 1,25(OH)₂D and waist circumference (β = -0,303, R² = 0.092, p = 0.01). These results were consistent after controlling by potential confounders.

In summary, the present results suggest that 1,25(OH)₂D plasma levels are not associated with either cardiometabolic risk factors or insulin resistance in healthy sedentary adults. However, an inverse association of 1,25(OH)₂D plasma levels with central adiposity was observed in our study sample.