Comparison Between Same-Day and Split-Dose Preparations with Sodium Picosulfate/Magnesium Citrate: A Randomized...

Area of Science:

• Gastroenterology
• Clinical Endoscopy
• Pharmacology

Background:

• Sodium picosulfate/magnesium citrate (SPMC) is a preferred small-volume bowel preparation agent.
• Limited data exists comparing same-day versus split-dose SPMC regimens for afternoon colonoscopies.
• Optimizing bowel preparation timing is crucial for colonoscopy efficacy.

Purpose of the Study:

• To compare the bowel cleansing efficacy of same-day versus split-dose SPMC preparations for afternoon colonoscopy.
• To evaluate the impact of colonoscopy timing (morning vs. afternoon) on bowel preparation quality.

Main Methods:

• A randomized, single-center, endoscopist-blinded, noninferiority study.
• Compared same-day (n=101) and split-dose (n=96) SPMC for afternoon colonoscopy.
• Assessed bowel cleansing using Aronchick Scale, Ottawa Bowel Preparation Scale (OBPS), Boston Bowel Preparation Scale (BBPS), and Bubble Scale.

Main Results:

• Both same-day and split-dose SPMC preparations demonstrated similar overall bowel cleansing efficacy.
• Same-day preparation showed a higher success rate (100% vs. 92.8%) on the Aronchick Scale.
• Same-day preparation achieved a better OBPS score (1.4 vs. 2.1), while BBPS scores were comparable (7.7 vs. 7.4).

Conclusions:

• Same-day SPMC preparation is non-inferior to split-dose preparation for afternoon colonoscopy.
• Same-day SPMC offers a viable and effective alternative for afternoon colonoscopy bowel preparation.
• Further research could explore patient preference and adherence for different SPMC timing regimens.