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Minimally Invasive Cisterna Magna Injection Model for Leptomeningeal Metastasis Studies in Mice
Published on: May 23, 2025
795
[Myelomatous meningitis: a case report].
Yuriko Aratake1, Ryosuke Takaya2, Katsuro Shindo1
1Department of Neurology, Kurashiki Central Hospital.
Rinsho Shinkeigaku = Clinical Neurology
|October 18, 2021
Summary
This case study highlights meningeal carcinomatosis in a multiple myeloma patient presenting with seizures. Early detection of central nervous system involvement is crucial for timely intervention.
Area of Science:
- Neurology
- Oncology
Background:
- Multiple myeloma can present with neurological complications, though central nervous system (CNS) involvement is rare.
- This case involves a 67-year-old woman with refractory multiple myeloma in remission.
Observation:
- The patient experienced tonic seizures and altered consciousness.
- Cerebrospinal fluid analysis revealed monoclonal CD 138-positive plasma cells.
- Cranial MRI demonstrated diffuse meningeal and cranial nerve enhancement.
Findings:
- Diagnosis of systemic epilepsy secondary to meningeal carcinomatosis was made.
- Treatment with antiepileptic drugs and intrathecal chemotherapy yielded minimal improvement.
- The patient succumbed to disease progression.
Implications:
- Meningeal carcinomatosis should be considered in multiple myeloma patients with neurological symptoms.
- Early diagnosis and prompt therapeutic intervention are vital for managing CNS involvement in multiple myeloma.
- This case underscores the importance of recognizing uncommon neurological manifestations of multiple myeloma.
