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Recognition of double-stranded DNA using LNA-modified toehold Invader probes.

Shiva P Adhikari1, Philip Vukelich1, Dale C Guenther1

  • 1Department of Chemistry, University of Idaho, Moscow, ID-83844, USA. hrdlicka@uidaho.edu.

Organic & Biomolecular Chemistry
|October 18, 2021
PubMed
Summary

New toehold Invader probes offer enhanced double-stranded DNA (dsDNA) recognition. These modified probes exhibit improved affinity and specificity, enabling the targeting of previously inaccessible DNA sequences.

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