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Radiotherapy biobanking: current landscape, opportunities, challenges, and future aspirations.

Tim H Ward1, Duncan C Gilbert2,3, George Higginbotham4

  • 1Patient Advocate, National Cancer Research Institute (NCRI), London, UK.

The Journal of Pathology. Clinical Research
|October 18, 2021
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Radiotherapy is crucial for cancer control, but predicting patient response remains challenging. Improving sample and data sharing in radiotherapy trials is essential for personalized cancer treatment.

Keywords:
biobankingradiotherapy

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Area of Science:

  • Oncology
  • Radiotherapy Research
  • Biomarker Discovery

Background:

  • Radiotherapy is a cornerstone of cancer treatment, used by 50% of patients for disease control.
  • Significant inter-patient variability exists in radiotherapy efficacy and toxicity, hindering personalized treatment.
  • Advancements in radiotherapy techniques and combination therapies necessitate better predictive biomarkers.

Purpose of the Study:

  • To survey current practices for collecting and sharing patient samples and data in UK radiotherapy trials.
  • To identify barriers hindering the collection and sharing of valuable research materials.
  • To propose solutions for improving the personalization of radiotherapy through enhanced data and sample accessibility.

Main Methods:

  • Survey of UK research groups involved in collecting patient materials from radiotherapy trials.
  • Analysis of current practices, barriers, and opportunities for sample and data sharing.
  • Literature review on the need for predictive biomarkers in radiotherapy.

Main Results:

  • Current practices for collecting and sharing patient samples and data in UK radiotherapy trials present significant barriers.
  • There is a missed opportunity to improve personalized radiotherapy due to fragmented data and sample accessibility.
  • Patients are willing to donate tissue samples for high-quality research.

Conclusions:

  • Standardizing patient information, consent forms, and data sets is crucial.
  • Greater patient involvement and easy linkage to clinical data would enhance sample and data discovery.
  • Increased national and international sharing of data and samples is vital for robust multicenter studies and avoiding duplicated efforts.