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Side effects of omeprazole: a system biology study
Maryam Hamzeloo-Moghadam1, Mostafa Rezaei Tavirani2, Somayeh Jahani-Sherafat3
1Traditional Medicine and Materia Medica Research Center and Department of Traditional Pharmacy, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Aim:
To assess the effects of omeprazole on the human cardiovascular system is the main aim of this study.
Background:
Omeprazole as a proton pump inhibitor is widely consumed to inhibit gastric acid secretion.
Methods:
Gene expression profiles of "human coronary artery endothelial cells" in the absence and presence of omeprazole were downloaded from the Gene Expression Omnibus (GEO) database. The differentially expressed genes (DEGs) interacted as an interactome, and the hub nodes are determined. The DEGs were enriched via gene ontology (GO) analysis. The critical hubs were identified based on the GO findings.
Results:
Among 103 queried DEGs, 61 individuals were included in the main connected component. CTNNB1, HNRNPA1, SRSF4, TRA2A, SFPQ, and RBM5 genes were identified as critical hub genes. Six clusters of biological terms were introduced as deregulated elements in the presence of omeprazole.
Conclusion:
In conclusion, long-term consumption of omeprazole may be accompanied with undesirable effects, however more evidence is required.
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Pharmacovigilance
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...