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Updated: Oct 16, 2025

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
Radium-223 Treatment in mCRPC Patient with Polycythemia Vera
Cristina de Angelis1, Viviana Frantellizzi1, Mariano Pontico2
1Sapienza University of Rome, Department of Radiological Sciences, Oncology and Anatomical Pathology, Rome, Italy
Abstract:
There have been several studies on the clinical outcomes of Radium-223 treatment in patients with metastatic castration-resistant prostate cancer (mCRPC) who may have an increased risk of hematologic comorbidities. To the best of our knowledge, this is the first study to explore the potential bone marrow adverse effects (AEs) of Radium-223 administered with specific drugs used for hematologic conditions, such as polycythemia vera (PV). We report the case of a patient with mCRPC who was administered a combined treatment of Radium-223 and hydroxyurea for PV, aiming to support clinicians in predicting eventual AEs.
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