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Metal-Organic Framework-Stabilized High Internal Phase Pickering Emulsions Based on Computer Simulation for Curcumin
Peihua Ma1, Jinglin Zhang1, Zi Teng1,2
1Department of Nutrition and Food Science, College of Agriculture and Natural Resources, University of Maryland, College Park, Maryland 20742, United States.
ACS Omega
|October 18, 2021
Summary
This study introduces a new delivery system using metal-organic framework (MOF)-stabilized high internal phase Pickering emulsions (HIPPEs) for hydrophobic compounds. This stable MOF-HIPPE system effectively encapsulates curcumin, showing promise for food and biomedical applications.
Area of Science:
- Materials Science
- Food Science
- Nanotechnology
Background:
- High internal phase Pickering emulsions (HIPPEs) offer high loading capacity and stability for delivery systems in the food industry.
- Metal-organic frameworks (MOFs) are versatile porous materials gaining traction in delivery research.
Purpose of the Study:
- To develop a novel MOF-stabilized HIPPE delivery system for hydrophobic phytochemicals.
- To utilize UiO-66-NH2 MOF nanoparticles for stabilizing HIPPEs.
- To evaluate the encapsulation of curcumin within the developed system.
Main Methods:
- Atomic simulation screening to select a suitable MOF (UiO-66-NH2).
- Solvothermal synthesis of UiO-66-NH2 nanoparticles (161.36 nm).
- Preparation of HIPPEs (50-80% inner phase ratio) via high-pressure homogenization and characterization of physicochemical properties.
- Loading curcumin into the MOF-HIPPE system.
Main Results:
- UiO-66-NH2 nanoparticles exhibited suitable amphiphilic properties for HIPPE stabilization.
- The MOF-HIPPE system demonstrated high loading capacity (6.93 ± 0.41%) and encapsulation efficiency (19.76 ± 3.84%) for curcumin.
- Systematic characterization of HIPPEs' crystallography, morphology, and rheology was performed.
Conclusions:
- A novel and stable MOF nanoparticle-stabilized HIPPE delivery system was successfully developed.
- This system shows significant potential for delivering hydrophobic bioactive components.
- The findings suggest future applications in food safety and biomedical fields.
