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Updated: Oct 16, 2025
Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor
Published on: February 16, 2018
Extremely Sensitive Molecularly Imprinted ECL Sensor with Multiple Probes Released from Liposomes Immobilized by a
Guangyan Liu1,2, Jun Ling1, Jianping Li1,2
1College of Environmental Science and Engineering, Guilin University of Technology, Guilin 541004, P. R. China.
Abstract:
A molecularly imprinted electrochemiluminescence sensor was prepared for sensitive and selective determination of aminotriazole via a novel strategy of multiple Ru(bpy)3Cl2 probes released from liposomes immobilized by a light-triggered click reaction. This sensing strategy provides a platform for trace detection of amino-containing pesticides. The target on the molecularly imprinted membrane connected to the Ru(bpy)3Cl2-encapsulated liposomes via the click reaction. After the destabilizing agent Triton X-100 was added, numerous Ru(bpy)3Cl2 molecules were released by liposomes on the molecularly imprinted polymer electrode. The ECL response of the sensor was linearly proportional to the logarithm of the aminotriazole concentration ranging from 5.00 × 10-18 to 1.00 × 10-12 mol/L, and the detection limit was 1.15 × 10-18 mol/L. The sensitivity of the detection was significantly improved, and the analysis process was simplified.
