Toolbox for Distal C-H Bond Functionalizations in Organic Molecules
Soumya Kumar Sinha1, Srimanta Guin1, Sudip Maiti1
1Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India.
Chemical Reviews
|October 18, 2021
Summary
Distal C-H functionalization, a challenging area of transition-metal catalysis, offers efficient synthetic routes. This review details methods, mechanisms, and scope for distal C-H bond activation in organic chemistry.
Area of Science:
- Synthetic organic chemistry
- Catalysis
Background:
- Transition-metal-catalyzed C-H activation provides novel retrosynthetic strategies.
- This methodology enhances the cost-effectiveness of synthesizing natural products and pharmaceuticals.
- Functionalization of proximal C-H bonds is well-established, but distal C-H functionalization remains challenging.
Purpose of the Study:
- To compile and review various methods for distal C-H bond functionalization.
- To provide mechanistic insights into these distal C-H activation procedures.
- To highlight the scope and limitations of current distal C-H functionalization techniques.
Main Methods:
- Review of existing literature on transition-metal-catalyzed C-H activation.
- Analysis of specialized techniques for distal C-H bond functionalization.
- Discussion of mechanistic pathways for various methods.
Main Results:
- Compilation of diverse methods for distal C-H functionalization.
- Detailed mechanistic explanations for successful distal C-H activation strategies.
- Assessment of the scope and limitations of these synthetic approaches.
Conclusions:
- Distal C-H activation has advanced significantly in synthetic organic chemistry.
- Current methods present challenges and areas for future development.
- Further synthetic modifications are needed to overcome existing pitfalls.
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