Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Protein Metabolism01:21

Overview of Protein Metabolism

2.3K
Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
2.3K
Muscle Recovery and Fatigue01:24

Muscle Recovery and Fatigue

3.1K
Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective...
3.1K
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

124
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
124
Proteins: Dietary Sources and Requirements01:28

Proteins: Dietary Sources and Requirements

858
Consuming animal-based products offers high-quality proteins that contain optimal levels and combinations of essential amino acids, crucial for tissue repair and growth. Foods like eggs, milk, fish, and most meats are a source of complete proteins. Legumes and cereals are abundant in proteins; however, they typically lack a full range of essential amino acids. As a result, they are considered incomplete protein sources. Some plant sources like soybeans, quinoa, and amaranth do contain complete...
858
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

4.7K
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
4.7K
Drug Dosing in Renal Diseases: Measurement of Serum Creatinine Concentration and Clearance01:25

Drug Dosing in Renal Diseases: Measurement of Serum Creatinine Concentration and Clearance

28
In healthy individuals, serum creatinine levels remain stable due to a balance between its constant production—primarily from muscle metabolism—and renal excretion. Creatinine is freely filtered by the glomeruli, making it a valuable marker for estimating renal function. When the glomerular filtration rate (GFR) decreases, the kidneys can only eliminate less creatinine, causing serum levels to rise.Serum creatinine concentration is widely used to estimate creatinine clearance...
28

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Does creatine supplementation improve strength and power in physically active individuals on a vegan diet? a randomized, triple-blind, placebo-controlled trial.

European journal of applied physiology·2026
Same author

Habitual creatine intake is associated with greater lean body mass and handgrip strength in the U.S. general population.

Nutrition and health·2026
Same author

The game of chess: Future directions for sports nutrition and supplementation.

Nutrition and health·2026
Same author

Creatine Supplementation Dose and Duration Are Not Associated with Increased Side Effects: A Structured Review and Study-Level Dose-Response Analysis of Randomized Controlled Trials.

Sports (Basel, Switzerland)·2026
Same author

A Perceptually Regulated Exercise Test for Predicting Maximal Oxygen Consumption in Masters Track-and-Field Athletes.

Journal of aging and physical activity·2026
Same author

Effects of Creatine Monohydrate Gummies on Performance and Body Composition in Female Beach Volleyball Athletes.

Journal of functional morphology and kinesiology·2026
Same journal

Developing Sodium Reduction Strategy: Context-Specific Frameworks Targeting Main Dietary Sources.

Advances in nutrition (Bethesda, Md.)·2026
Same journal

The Appearance of Validity in Nutrition Science: Why Weak Inferences Persist.

Advances in nutrition (Bethesda, Md.)·2026
Same journal

Immunonutrition Decreases Postoperative Complications in Gastrointestinal Cancer - A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Advances in nutrition (Bethesda, Md.)·2026
Same journal

Stunting reversal versus regression to the mean in epidemiological studies of child linear growth in low- and middle-income countries.

Advances in nutrition (Bethesda, Md.)·2026
Same journal

The Pharmacological Window Hypothesis: How Emerging Obesity Medications May Realize Decades of Plant-Forward Dietary Recommendations.

Advances in nutrition (Bethesda, Md.)·2026
Same journal

Opportunities for Individual- and Population-Specific Adaptations in Food Is Medicine: A Scoping Review.

Advances in nutrition (Bethesda, Md.)·2026
See all related articles

Related Experiment Video

Updated: Oct 16, 2025

Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle
09:40

Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle

Published on: January 19, 2017

11.9K

Perspective: Creatine, a Conditionally Essential Nutrient: Building the Case.

Sergej M Ostojic, Scott C Forbes

    Advances in Nutrition (Bethesda, Md.)
    |October 18, 2021
    PubMed
    Summary
    This summary is machine-generated.

    Creatine is vital for energy metabolism but the body may not produce enough. Dietary creatine intake is essential for human health, potentially making it a conditionally essential nutrient.

    Keywords:
    creatinedeficiencyfoodgrowthmeatvegetarians

    More Related Videos

    Measurement of Protein Import Capacity of Skeletal Muscle Mitochondria
    09:01

    Measurement of Protein Import Capacity of Skeletal Muscle Mitochondria

    Published on: January 7, 2022

    2.8K
    Quantification of Subcellular Glycogen Distribution in Skeletal Muscle Fibers using Transmission Electron Microscopy
    08:32

    Quantification of Subcellular Glycogen Distribution in Skeletal Muscle Fibers using Transmission Electron Microscopy

    Published on: February 7, 2022

    4.4K

    Related Experiment Videos

    Last Updated: Oct 16, 2025

    Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle
    09:40

    Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle

    Published on: January 19, 2017

    11.9K
    Measurement of Protein Import Capacity of Skeletal Muscle Mitochondria
    09:01

    Measurement of Protein Import Capacity of Skeletal Muscle Mitochondria

    Published on: January 7, 2022

    2.8K
    Quantification of Subcellular Glycogen Distribution in Skeletal Muscle Fibers using Transmission Electron Microscopy
    08:32

    Quantification of Subcellular Glycogen Distribution in Skeletal Muscle Fibers using Transmission Electron Microscopy

    Published on: February 7, 2022

    4.4K

    Area of Science:

    • Nutritional Science
    • Human Physiology
    • Biochemistry

    Background:

    • Creatine is crucial for energy metabolism in skeletal muscle, brain, and heart.
    • It's synthesized internally and obtained from diet, supporting growth, development, and health.
    • Recent research indicates endogenous creatine synthesis may be insufficient for optimal human needs.

    Purpose of the Study:

    • To review arguments supporting creatine as a conditionally essential nutrient.
    • To identify key research questions for future investigation into creatine's nutritional role.

    Main Methods:

    • Literature review and synthesis of current research on creatine metabolism and nutrition.
    • Analysis of physiological requirements versus endogenous production of creatine.
    • Identification of knowledge gaps and areas for future research.

    Main Results:

    • The body's natural creatine synthesis may not meet physiological demands.
    • Dietary creatine intake is necessary to achieve optimal creatine levels.
    • Circumstances exist where creatine functions as an essential nutrient.

    Conclusions:

    • Creatine should be considered a conditionally essential nutrient for humans.
    • Further research is needed to fully understand creatine requirements and its role in human health.
    • Investigating specific populations and conditions where creatine supplementation is beneficial is warranted.