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Updated: Oct 16, 2025

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
Published on: July 30, 2017
Enhancing catalytic activity of pyridines via para-iminophosphorano substituents
Nicholas A Richard1, Grant D Charlton1, C Adam Dyker1
1Department of Chemistry, University of New Brunswick, Fredericton, New Brunswick, E3B 5A3, Canada. cadyker@unb.ca.
Abstract:
Four pyridines decorated with π-donating iminophosphorano substituents (R3PN-) in the 4-position were assessed as acylation catalysts. These catalysts display high sensitivity to the groups at phosphorus, with activities that are well correlated to the corresponding Hammett-type substituent constants (σp+), and can achieve superior activity over the most active dialkylamino-substituted pyridines. Iminophosphorano-substituted pyridines represent an easily accessible, tunable, and highly active class of nucleophilic organocatalysts.
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