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Updated: Oct 16, 2025

Designing a Bio-responsive Robot from DNA Origami

Designing a Bio-responsive Robot from DNA Origami

Published on: July 8, 2013

Biomimetic DNA Nanotechnology to Understand and Control Cellular Responses.

Soumya Sethi¹, Hiroshi Sugiyama^1,2, Masayuki Endo^1,2,3

¹Department of Chemistry, Graduate School of Science, Kyoto University, Yoshida-ushinomiyacho, Sakyo-ku, Kyoto, 606-8501, Japan.

Chembiochem : a European Journal of Chemical Biology

|October 19, 2021

Summary

DNA nanotechnology offers a versatile toolkit for mimicking cellular interactions. This review explores its use in understanding cell-matrix, cell-cell, and cell-ligand dynamics, paving the way for future innovations.

Keywords:

DNA nanotechnology cell adhesion cell morphology control mechanical DNA polymers photoswitch

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Last Updated: Oct 16, 2025

Designing a Bio-responsive Robot from DNA Origami

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Published on: July 8, 2013

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

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Folding and Characterization of a Bio-responsive Robot from DNA Origami

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

Area of Science:

Biotechnology
Nanotechnology
Cell Biology

Background:

Cells receive cues from the extracellular matrix (ECM), neighboring cells, and ligands to regulate functions like adhesion, interaction, proliferation, and differentiation.
Understanding and controlling these in vitro cellular functions requires detailed knowledge of these nanocues.

Purpose of the Study:

To review advances in using DNA nanotechnology to mimic and study cell-matrix, cell-cell, and cell receptor-ligand interactions.
To highlight the potential and challenges of DNA-based nanostructures in cell biology research.

Main Methods:

Review of existing literature on DNA nanotechnology applications in cell biology.
Focus on studies employing DNA nanostructures to replicate biological interactions at the molecular level.

Main Results:

DNA nanotechnology provides a biocompatible and flexible toolkit for mimicking complex cellular interactions.
Demonstrated success in creating nanostructures that replicate cell-matrix, cell-cell, and receptor-ligand dynamics.

Conclusions:

DNA nanotechnology is a powerful tool for elucidating and manipulating cellular functions in vitro.
Future innovations in regenerative medicine, drug delivery, and diagnostics can be inspired by these DNA-based nanostructures.