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Updated: Oct 16, 2025
Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery
Published on: June 23, 2020
Polyelectrolyte/Gold Nanoparticle Nanotubes Incorporating Doxorubicin-Loaded Liposomes
Yuto Enomoto1, Motofusa Akiyama1, Yoshitsugu Morita1
1Department of Applied Chemistry, Faculty of Science and Engineering, Chuo University, 1-13-27 Kasuga, Bunkyo-ku, Tokyo, 112-8551, Japan.
Abstract:
Anticancer agent doxorubicin-loaded liposomes (DoxLs) were drawn spontaneously into nanotubes comprising multilayers of polyelectrolytes and gold nanoparticles (PAuNTs). We describe a unique structure of PAuNTs incorporating DoxLs (DoxL-PAuNT). The number of DoxLs adsorbed on the tube interior surface was ascertained as 2.4×103 . Heating stimuli engendered gel-liquid crystal phase transition of DoxL in the capillary, subsequently inducing efficient release of Dox without structural changes of the tubule or liposome. Furthermore, antitumor activity of the DoxL-PAuNTs on cancer cells was elucidated.
