A helix foldamer oligopeptide improves intracellular stability and prolongs protein expression of the delivered mRNA
Satoshi Uchida1,2, Yuto Yamaberi3, Masakazu Tanaka3
1Medical Chemistry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan. moba@koto.kpu-m.ac.jp.
Nanoscale
|October 19, 2021
Abstract:
Prolonging the duration of protein expression from mRNA is a major challenge in the development of mRNA nanomedicines. mRNA complexed with helix foldamer oligopeptides consisting of arginine and α-aminoisobutyric acids showed higher intracellular stability than that complexed with oligoarginines, thereby maintaining efficient protein translation for three days.
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