Neutrophils with ring-shaped nuclei in chronic neutrophilic leukemia

A significant incidence of neutrophils with ring-shaped nuclei was observed in all of four patients with chronic neutrophilic leukemia. The present data may give further support for the view that chronic neutrophilic leukemia is not a reactive disorder but a rare form of myeloproliferative disorder. It seems possible that this phenomenon can be used as a marker for abnormal granulopoiesis in human diseases.