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Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss
Published on: July 19, 2024
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New targets for NAFLD.
Lucia Parlati1,2, Marion Régnier3, Hervé Guillou4
1Université de Paris, Institut Cochin, CNRS, INSERM, F- 75014 Paris, France.
JHEP Reports : Innovation in Hepatology
|October 20, 2021
Summary
Non-alcoholic fatty liver disease (NAFLD) is a widespread liver condition. This review updates on NAFLD molecular pathways and potential new treatments, as effective therapies are currently lacking.
Area of Science:
- Hepatology
- Molecular Biology
- Gastroenterology
Background:
- Non-alcoholic fatty liver disease (NAFLD) is a prevalent condition globally.
- NAFLD is characterized by fat accumulation, inflammation, liver cell injury, and fibrosis.
- Current treatment options for NAFLD are limited.
Purpose of the Study:
- To review the molecular pathways implicated in NAFLD pathophysiology.
- To highlight emerging therapeutic targets for NAFLD treatment.
Main Methods:
- Literature review of preclinical models (dietary and genetic).
- Analysis of molecular pathways involved in NAFLD.
- Survey of ongoing therapeutic target studies.
Main Results:
- Detailed overview of NAFLD molecular mechanisms.
- Identification of several potential therapeutic targets.
- Summary of progress in understanding NAFLD aetiology.
Conclusions:
- NAFLD pathogenesis is complex, involving multiple molecular pathways.
- Further research into these pathways may yield effective treatments.
- Targeting specific molecular pathways offers promise for future NAFLD therapies.
Keywords:
ACC, acetyl-CoA carboxylaseASK1, apoptosis signal-regulating kinase 1CAP, controlled attenuation parameterChREBPChREBP, carbohydrate responsive element–binding proteinFAS, fatty acid synthaseFFA, free fatty acidFGF21, fibroblast growth factor-21FXRFXR, farnesoid X receptorGGT, gamma glutamyltransferaseHCC, hepatocellular carcinomaHFD, high-fat dietHSC, hepatic stellate cellsHSL, hormone-sensitive lipaseHVPG, hepatic venous pressure gradientIL-, interleukin-JNK, c-Jun N-terminal kinaseLXRLXR, liver X receptorMCD, methionine- and choline-deficientMUFA, monounsaturated fatty acidsNAFLDNAFLD, non-alcoholic fatty liver diseaseNASHNASH, non-alcoholic steatohepatitisNEFANEFA, non-esterified fatty acidPPARαPPARα, peroxisome proliferator-activated receptor-αPUFAs, polyunsaturated fatty acidsPY, persons/yearsPhf2, histone demethylase plant homeodomain finger 2RCT, randomised controlled trialSCD1, stearoyl-CoA desaturase-1SFA, saturated fatty acidSREBP-1cSREBP-1c, sterol regulatory element–binding protein-1cTCA, tricarboxylic acidTLR4, Toll-like receptor 4TNF-α, tumour necrosis factor-αVLDL, very low-density lipoproteinanimal modelsglucotoxicitylipotoxicity
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