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Updated: Oct 16, 2025

Synthesis of Wavelength-shifting DNA Hybridization Probes by Using Photostable Cyanine Dyes
Published on: July 6, 2016
Multiple phenyl ring appended Re-based complexes for strong visible light absorption and DNA binding
Bholey Singh1, Balaram Pani1, Deepak Gupta1
1Department of Chemistry, Bhaskaracharya College of Applied Sciences (University of Delhi), Sector-2, Dwarka, New Delhi, 110075, India. deepakg2003@gmail.com.
Abstract:
A series of facial-Re(CO)3-based acyclic complexes (1-3) possessing N∩O bis-chelating ligands and a triphenylphosphine oxide donor was synthesized and characterized. The most interesting structural feature of these complexes is that both the coordinated ligands are functionalized with external phenyl rings. Single crystal X-ray diffraction analysis confirms that each molecule demonstrates a variety of intermolecular supramolecular interactions via the external phenyl rings. All the complexes displayed strong absorption (ε = 14 000-40 000 M-1 cm-1) over wide visible region (400-600 nm). Due to the interesting structural and photophysical properties of the complexes, a satisfactory DNA binding ability was observed. The binding of the complexes with DNA grooves was confirmed by a significant increase in the absorption intensities of the complexes in the visible region, absorption enhancement of DNA and circular dichroism.
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