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Metabolic Syndrome and Cognitive Function.

Mouna Tahmi1, Priya Palta2,3, José A Luchsinger2,3

  • 1Department of Medicine, College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA. mt3288@cumc.columbia.edu.

Current Cardiology Reports
|October 20, 2021
PubMed
Summary
This summary is machine-generated.

Metabolic syndrome (MetS) is linked to poorer cognitive function and increased risk of mild cognitive impairment (MCI) and dementia. Further research is needed on MetS prevention and treatment

Keywords:
Cardiovascular risk factorCognitionCognitive impairmentDementiaMetabolic syndrome

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Area of Science:

  • Neuroscience
  • Cardiology
  • Endocrinology

Background:

  • Metabolic syndrome (MetS) comprises cardiovascular disease risk factors.
  • MetS is associated with adverse health outcomes, including cognitive decline.

Purpose of the Study:

  • To review recent findings on the association between MetS and cognitive function.
  • To critically evaluate the relationship between MetS and cognition.

Main Methods:

  • Literature review of recent cross-sectional and longitudinal studies.
  • Analysis of associations between MetS, its components, and cognitive outcomes.

Main Results:

  • Most cross-sectional studies show MetS is linked to lower cognitive function.
  • Longitudinal findings are inconsistent, varying by age, sex, and study duration.
  • MetS increases the risk of mild cognitive impairment (MCI) and dementia, especially vascular dementia.
  • Hypertension, central obesity, and hyperglycemia are key predictors of cognitive impairment.

Conclusions:

  • Metabolic syndrome is associated with an elevated risk of cognitive impairment.
  • Further research is required to understand the impact of MetS prevention and treatment on cognition.