Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Liver Regeneration01:24

Liver Regeneration

3.5K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
3.5K
Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

1.4K
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
1.4K
Hepatic Portal System01:21

Hepatic Portal System

2.9K
The hepatic portal system, a critical part of our circulatory framework, transports nutrient-laden, deoxygenated blood from the gastrointestinal tract and spleen to the liver. This ingenious system plays an indispensable role in maintaining our body's metabolic equilibrium.
At its core, the hepatic portal vein is the result of a confluence of the superior and inferior mesenteric veins along with the splenic vein. Each of these veins has a unique role. The superior mesenteric vein is...
2.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Short-term mortality is reduced and low grade ACLF reversed by TIPS in patients with fluid overload: a case-control study.

Clinical and translational gastroenterology·2026
Same author

A myeloid immunosuppressive phenotype defines primary refractoriness to atezolizumab Plus bevacizumab in hepatocellular caarcinoma.

Journal of hepatology·2026
Same author

Nivolumab in combination with lenvatinib in unresectable hepatocellular carcinoma: The IKF-t006/IMMUNIB translational phase-2 study.

European journal of cancer (Oxford, England : 1990)·2026
Same author

High-dimensional Spatial Immune Profiling Highlights Microglia-Like Cells in Human Dorsal Root Ganglia.

European journal of immunology·2026
Same author

12-HETE: a novel lipid mediator of CD8<sup>+</sup> T cell dysfunction in MASH/HCC.

Gut·2026
Same author

FAS-controlled T cells drive lymphoproliferation through glycolysis without effector differentiation.

Journal of human immunity·2026
Same journal

Deutsche medizinische Wochenschrift (1946)·2026
Same journal

["Not everything that looks like a tumor..." - Pulmonary tularemia with hilar lymphadenopathy].

Deutsche medizinische Wochenschrift (1946)·2026
Same journal

[Emergency management of sickle cell disease].

Deutsche medizinische Wochenschrift (1946)·2026
Same journal

[Hereditary dehydrated stomatocytosis (= hereditary xerocytosis) - Interesting hummingbird or clinically relevant diagnosis?]

Deutsche medizinische Wochenschrift (1946)·2026
Same journal

[Diagnosis of Congenital Hemolytic Anemias in Adults].

Deutsche medizinische Wochenschrift (1946)·2026
Same journal

[46-year-old female patient with right upper abdominal pain].

Deutsche medizinische Wochenschrift (1946)·2026
See all related articles

Related Experiment Video

Updated: Oct 16, 2025

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
12:24

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

Published on: September 30, 2021

5.5K

[Hepatocellular Carcinoma].

Michael Schultheiß, Bertram Bengsch, Robert Thimme

    Deutsche Medizinische Wochenschrift (1946)
    |October 20, 2021
    PubMed
    Summary
    This summary is machine-generated.

    Hepatocellular carcinoma (HCC), a common cancer, is increasingly diagnosed at advanced stages. New treatments like immunotherapy (atezolizumab with bevacizumab) offer improved outcomes for advanced liver cancer.

    More Related Videos

    An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
    06:38

    An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis

    Published on: September 12, 2019

    9.1K
    Generation of Subcutaneous and Intrahepatic Human Hepatocellular Carcinoma Xenografts in Immunodeficient Mice
    10:35

    Generation of Subcutaneous and Intrahepatic Human Hepatocellular Carcinoma Xenografts in Immunodeficient Mice

    Published on: September 25, 2013

    36.4K

    Related Experiment Videos

    Last Updated: Oct 16, 2025

    A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
    12:24

    A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

    Published on: September 30, 2021

    5.5K
    An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
    06:38

    An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis

    Published on: September 12, 2019

    9.1K
    Generation of Subcutaneous and Intrahepatic Human Hepatocellular Carcinoma Xenografts in Immunodeficient Mice
    10:35

    Generation of Subcutaneous and Intrahepatic Human Hepatocellular Carcinoma Xenografts in Immunodeficient Mice

    Published on: September 25, 2013

    36.4K

    Area of Science:

    • Hepatology
    • Oncology
    • Gastroenterology

    Background:

    • Hepatocellular carcinoma (HCC) incidence is rising globally, posing a significant public health challenge.
    • Liver cirrhosis, chronic hepatitis B, and non-alcoholic steatohepatitis (NASH) are primary risk factors for HCC development.
    • Despite surveillance, most HCC cases are diagnosed at advanced Barcelona Clinic Liver Cancer (BCLC) stages, limiting curative treatment options.

    Purpose of the Study:

    • To review current treatment strategies for Hepatocellular Carcinoma (HCC) across different BCLC stages.
    • To highlight recent advancements in systemic therapies, particularly immunotherapy, for advanced HCC.
    • To provide an overview of therapeutic options based on disease stage and patient condition.

    Main Methods:

    • Literature review of Hepatocellular Carcinoma (HCC) treatment guidelines and clinical trials.
    • Analysis of therapeutic efficacy for early, intermediate (BCLC stage B), and advanced (BCLC stage C) HCC.
    • Examination of systemic treatments including immunotherapy and tyrosine kinase inhibitors (TKIs).

    Main Results:

    • Curative treatments like liver resection, transplantation, and ablation are effective for early-stage HCC.
    • Transarterial chemoembolization (TACE) and selective internal radiation therapy (SIRT) improve tumor control in BCLC stage B HCC.
    • Atezolizumab combined with bevacizumab is the new first-line therapy for BCLC stage C HCC; TKIs serve as alternatives or second-line options.

    Conclusions:

    • Treatment of Hepatocellular Carcinoma (HCC) is stage-dependent, with significant progress in systemic therapies for advanced disease.
    • Immunotherapy represents a major advancement in HCC management, offering new hope for patients with advanced liver cancer.
    • Personalized treatment approaches considering BCLC stage and patient factors are crucial for optimizing HCC outcomes.