[Advances in basic and translational research in neuroendocrine neoplasms]

Area of Science:

• Oncology
• Molecular Biology
• Translational Medicine

Background:

• Increasing detection rates and clinical attention on neuroendocrine tumors (NETs).
• NETs present challenges due to heterogeneity, leading to metastasis and recurrence.
• Current NET efficacy necessitates further investigation into biological behaviors.

Purpose of the Study:

• To review recent advancements in neuroendocrine tumor research.
• To highlight key areas including multiomics, tumor microenvironment, and preclinical models.
• To discuss the clinical transformation significance of these research areas.

Main Methods:

• Focus on multiomics data: copy number variation, genomics, and transcriptomics.
• Analysis of the tumor microenvironment: immune microenvironment, tumor microvasculature, and fibroblasts.
• Evaluation of preclinical research models: cell lines, organoids, patient-derived xenografts, and genetically engineered mice.

Main Results:

• Multiomics approaches reveal insights into NET heterogeneity.
• Tumor microenvironment components significantly influence NET progression.
• Advanced preclinical models facilitate better understanding and testing of NET therapies.

Conclusions:

• Continued research into multiomics and tumor microenvironment is crucial for understanding NETs.
• Development and utilization of sophisticated preclinical models are vital for clinical translation.
• Integrating these findings promises to improve neuroendocrine tumor treatment efficacy.