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Serum CA-125 antigen levels increase during menses.
American Journal of Obstetrics and Gynecology
|January 1, 1987
Summary
Elevated serum cancer antigen 125 (CA-125) levels were observed during menstruation in women with and without endometriosis. Menstrual blood samples may lead to inaccurate endometriosis diagnoses due to these temporary increases.
Area of Science:
- Gynecology
- Oncology
- Clinical Chemistry
Background:
- Cancer antigen 125 (CA-125) is a tumor marker often monitored in women's health.
- Endometriosis diagnosis can be challenging, and reliable biomarkers are crucial.
Purpose of the Study:
- To investigate the impact of menstruation on serum CA-125 levels.
- To assess the implications of these changes for endometriosis diagnosis.
Main Methods:
- Serum CA-125 levels were measured using radioimmunoassay.
- Measurements were taken before and during menses in women with and without endometriosis.
Main Results:
- A significant increase in mean CA-125 levels was observed during menses in both study groups.
- This suggests menstruation itself can elevate CA-125 antigen levels.
Conclusions:
- Menstrual timing is a critical factor when interpreting serum CA-125 levels.
- Elevated CA-125 during menses may result in false positive results, potentially complicating endometriosis diagnosis.