MiR-873-5p: A Potential Molecular Marker for Cancer Diagnosis and Prognosis

Area of Science:

• Molecular Biology
• Genetics
• Oncology

Background:

• MicroRNA-873 (miR-873) is a microRNA located on chromosome 9p21.1, with miR-873-5p and miR-873-3p as its main members.
• While miR-873-5p is the focus of most research, miR-873-3p has received less attention.
• miR-873-5p expression is altered in numerous cancers, being down-regulated in 14 and up-regulated in 4 types.

Purpose of the Study:

• To review the role and mechanisms of miR-873-5p in human tumors.
• To explore the potential of miR-873-5p as a molecular marker for cancer diagnosis and prognosis.

Main Methods:

• Literature review summarizing existing studies on miR-873-5p in cancer.
• Analysis of miR-873-5p's targeted genes and their molecular functions.
• Investigation of miR-873-5p's involvement in key cancer-related signaling pathways.

Main Results:

• miR-873-5p targets genes involved in catalytic activity, transcription regulation, and binding.
• It influences cancer development via PIK3/AKT/mTOR, Wnt/β-Catenin, NF-κβ, and MEK/ERK pathways.
• Target genes are linked to cancer cell proliferation, apoptosis, migration, invasion, cell cycle, stemness, and glycolysis.
• miR-873-5p affects anti-cancer drug efficacy and its expression is epigenetically regulated.

Conclusions:

• miR-873-5p is a significant factor in human tumorigenesis.
• Its multifaceted roles suggest potential as a biomarker for cancer diagnosis and prognosis.
• Further research into miR-873-5p mechanisms could lead to novel therapeutic strategies.