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Estimating the risk of thrombotic events in people with congenital hemophilia A using US claims data

Imi Faghmous1,2, Francis Nissen1, Peter Kuebler3

  • 1Real-World Data Oncology-Hematology, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, Basel, 4070, Switzerland.

Journal of Comparative Effectiveness Research
|October 22, 2021
PubMed

Aim: Compare thrombotic risk in people with congenital hemophilia A (PwcHA) to the general non-hemophilia A (HA) population. Patients & methods: US claims databases were analyzed to identify PwcHA. Incidence rates of myocardial infarction, pulmonary embolism, ischemic stroke, deep vein thrombosis and device-related thrombosis were compared with a matched cohort without HA. Results: Over 3490 PwcHA were identified and 16,380 individuals matched. PwcHA had a similar incidence of myocardial infarction and pulmonary embolism compared with the non-HA population, but a slightly higher incidence of ischemic stroke and deep vein thrombosis. The incidence of device-related thrombosis was significantly higher in PwcHA. Conclusion: This analysis suggests that PwcHA are not protected against thrombosis, and provides context to evaluate thrombotic risk of HA treatments.

Keywords:
hemophilia Ahemostasisischemic strokemyocardial infarctionpulmonary embolismtherapeuticsthrombosisvascular access devicesvenous thrombosis

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